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Scientists were on the verge of a breakthrough on gene splicing

Posted on October 28, 2025 by Joke Poo

They crossed the DNA of a crab with that of a cheetah. But from there, things went sideways very quickly

Okay, here’s my attempt at a “Joke Poo” based on the gene splicing joke, titled “Software Bug”:

Joke Poo: Software Bug

Software engineers were celebrating a potential AI milestone. They successfully merged the code of a Roomba vacuum cleaner with that of a sophisticated chess-playing program. But from there, things went terribly wrong… it kept trying to strategically corner dust bunnies and sacrificing them for board control.

Alright, let’s crack this crab-cheetah combo joke open!

Joke Dissection:

  • Premise: Scientists attempt gene splicing, a modern and complex scientific pursuit.
  • Setup: Mixing the DNA of a crab and a cheetah, a seemingly absurd combination. This creates a bizarre mental image.
  • Punchline: “But from there, things went sideways very quickly.” This is the payoff, relying on the ambiguity and implied chaos of what the resulting creature might be (and the visual pun of a crab going sideways).
  • Humor Source: The humor comes from the unexpectedness of combining these animals, the absurdity of the experiment, and the vague but evocative punchline suggesting a hilariously unsuccessful outcome. It also plays on our understanding of how complicated and unpredictable genetic engineering can be in reality.

Key Elements:

  • Gene Splicing/Genetic Engineering: This is the core scientific concept.
  • Crab: A sideways-walking, shelled creature of the sea.
  • Cheetah: The fastest land animal, known for its speed and agility.
  • Unexpected Combination: The juxtaposition of the crab and cheetah.
  • “Sideways”: Plays on the physical movement of the crab and the figurative meaning of things going wrong.

Comedic Enrichment: New Joke/Observation/Did You Know:

Option 1: Enhanced Joke

“Scientists thought they were on the verge of a breakthrough on gene splicing. They crossed the DNA of a crab with that of a cheetah, hoping for a super-fast, shell-protected marine reconnaissance unit. But from there, things went sideways – literally. Turns out, giving a cheetah pincers just makes it pinch your ankles really fast. The crab part? It learned to purr. Loudly.”

Why it works: This adds a little more specificity to the disaster. The intention behind the gene-splicing is now revealed, and the outcome is made more concrete (and hilarious). The reversal – crab part learns to purr – is unexpected and enhances the joke’s absurdity.

Option 2: Witty Observation/Joke (Focusing on “Sideways”)

“Gene splicing: It’s like life. You think you’re going forward, but sometimes you end up scuttling sideways and pinching someone’s ankles. Just ask the crab-cheetah hybrid… or my last relationship.”

Why it works: Relates the specific concept to a broader and relatable idea. The crab-cheetah hybrid serves as a specific example of a more general (and relatable) situation.

Option 3: “Did You Know?”/Joke

“Did you know cheetahs can only maintain their top speed of around 75 mph for short bursts? Imagine how disappointing it must have been for the crab-cheetah hybrid – all that potential, wasted on sideways bursts of 5 mph. At least it still got to enjoy the beach, sideways. With a helmet.”

Why it works: This blends factual information with absurd speculation. The “did you know” format adds a layer of mock-authenticity to the ridiculous premise. The helmet bit puts the cherry on top.

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